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Immune System Modulation with Muramyl Peptides, Beta-1,3-glucan, and
Calcium D-glucarate


The Immune system’s primary function is to protect the body from infection and cancerous changes to normal cells. Support and enhancement of the immune system is an essential step to an anti-aging program.

Immune weakness: Recurrent or chronic infections occur when the immune system is weakened. A cycle exists that must be interrupted: weakened immune system leads to infection, infection damages or exhausts immune system, which weakens resistance.

Hyper responsive Immune System: The immune system can also be hyperalert. This is seen in autoimmune diseases when the body starts attacking itself.

Both the weakened immune system and the hyperaleret immune system need immune system modulation. This section of the web site will show you how you can use the latest techniques for Immune System Modulation.

Components of the Immune System

The immune system is composed of the following tissues:

  1. Lymphatic vessels (your lymph nodes, thymus, spleen, and tonsils)
  2. White blood cells (lymphocytes, neutrophils, eosinophils, monocytes and basophils)
  3. Specialized cells in the tissue (macrophages, mast cells)
  4. Specialized chemical factors (interleukin II, interferon, complement fractions etc.)
  5. The Gut Associated Lymphoid Tissue (GALT), a very important lymphatic tissue that surrounds your gastrointestinal tract.

Key Nutrients For the Immune System
and Detoxification

  1. Muramyl peptides,
  2. Beta- 1,3-glucan,
  3. Calcium D-glucarate

Muramyl peptide and Beta- 1,3-glucan

There has been much research in the last few years on the immune boosting effects of various mushrooms. Reishi, Maitake, Shitake and Cordyceps mushrooms have been used for thousands of years in China and India for their ability to promote good health. It is clear from the research that certain components of these mushrooms called polysaccharides have the ability to increase and stimulate our body’s immune response to viruses, bacteria and funguses. One of these molecules is Beta-1,3-glucan.

A similar response has been shown to occur with potent polysaccharides extracted from the cell walls of bacteria. This may be why probiotics, such as Lactobacillus and Acidophilus, have positive health effects. One of these nontoxic cell wall extracts is a molecule called Muramyl peptide. It is an extract from a bacteria called Lactobacillus fermentum. The immune system recognizes the Muramyl peptide, identifies it as being of bacterial origin and increases the immune response accordingly.

The effect of Beta-1,3-glucan and Muramyl peptide is to stimulate the immune system, raise the alert to potential invading pathogens, and increase the secretion of potent immune chemical messengers in the body called cytokines and interleukins, which send messages to the white blood cells and the immune system to become more active. Muramyl peptides and Beta-1,3-glucan also increase the ability of certain white blood cells called macrophages to seek out and destroy cells that have been infected by viruses, which is very important for those who have been exposed to the flu virus, or other viruses such as herpes, HIV, etc.

Calcium D-glucarate

Calcium d-glucarate is a nontoxic, natural substance found in high concentrations in fruits and vegetables. The benefits of d-glucarate were first discovered by researchers at the M.D. Anderson Cancer Center. Many studies have shown it to be highly protective against cancer due to properties that increase the ability of the body to detoxify and eliminate toxins and other harmful substances. Calcium d-glucarate is also an effective product for removing excess hormones and foreign chemicals that have negative hormonal activity in the body. This may be one of the reasons that d-glucarate is important in protecting against breast cancer and controlling postmenopausal symptoms. I feel that d-glucarate’s role in improving your body’s immunity lies in its ability to process and eliminate harmful toxins and carcinogens that tax the immune system, and also in its ability to bind to and remove toxic cellular waste. By increasing the levels of d-glucarate your body will have to spend less energy eliminating harmful substances. Energy that can be better used to fight incoming infections. There is also increasing evidence that d-glucarate has antibacterial and antiviral properties.
Too many toxic estrogens in the body fat can increase body fat and water retention in both men and women, Calcium d-glucarate has the ability to neutralize these toxic estrogens leading to a leaner and healthy body. Click Here for more details on Calcium d-glucarate and detoxification.


Taken together, Muramyl peptides, beta-1,3-glucan, and calcium d-glucarate form a synergy that enhances the functioning of the body. While calcium D-glucarate detoxifies the system, it also prepares the way for Muramyl peptides to support healthy immune function. Taking a regular dose of these products during the flu season will prepare your body very well for the Spring, which is a great time to begin to cleanse and detoxify.

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Statements made on this website have not been evaluated by the Food and Drug Administration. Information on these pages is not intended to diagnose, treat, cure or prevent disease. © 2005 Weatherby & Associates, LLC. All rights reserved